Tumefactive demyelinating lesion

A tumefactive demyelinating lesion is a solitary large (usually over 2cm) inflammatory demyelinating lesion which can give the appearance of a tumor without tissue swelling around the lesion (unlike a tumor).

Prognosis is generally more positive with a tumefactive demyelinating lesion compared with other forms of demyelination such as multiple sclerosis (MS), and it is unusual for someone who presents with a solitary tumefactive lesion to develop multiple sclerosis.